FAB-BASED INHIBITORS REVEAL UBIQUITIN INDEPENDENT FUNCTIONS FOR HIV VIF NEUTRALIZATION OF APOBEC3 RESTRICTION FACTORS.

Fab-based inhibitors reveal ubiquitin independent functions for HIV Vif neutralization of APOBEC3 restriction factors.

The lentiviral protein Viral Infectivity Factor (Vif) counteracts the antiviral effects of host APOBEC3 (A3) proteins Rice and contributes to persistent HIV infection.Vif targets A3 restriction factors for ubiquitination and proteasomal degradation by recruiting them to a multi-protein ubiquitin E3 ligase complex.Here, we describe a degradation-ind

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Mesoscale Model to Select the Ideal Location for New Vineyard Plantations in the Rioja Qualified Denomination of Origin

La Rioja is the region where the top rated wines from Spain come from and also the origin of one of the most prestigious wines in the world.It is worldwide recognized, not only for the quality of the vine, but also for the many factors involved in the process that are controllable by the farmer, such as fertilizers, irrigation, etc.Likewise, there

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All-synchronized picosecond pulses and time-gated detection improve the spatial resolution of two-photon STED microscopy in brain tissue imaging

Super-resolution in two-photon excitation (2PE) microscopy offers new approaches for visualizing the deep inside the brain functions at the nanoscale.In this study, we developed a novel 2PE stimulated-emission-depletion (STED) microscope with all-synchronized picosecond pulse light sources and Color additives time-gated fluorescence detection, name

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